Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

3'UTR regulation of axon translation and optic nerve regeneration.

Molecular neurodegeneration·2026

Same author

Corrigendum to "Oculomics and AI: The eye as a biomarker for health span" [Asia-Pac J Ophthalmol 15 (1) (2026) 100282].

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2026

Same author

Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing.

Biomedical optics express·2026

Same author

Reply.

Ophthalmology science·2026

Same author

Safety of insulin eye drops in the tratment of open angle glaucoma: a randomized phase I clinical trial.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026

Same author

Biomechanical Modification of the Sclera: An Ex Vivo Study on Porcine Eyes.

Investigative ophthalmology & visual science·2026

Same journal

Adjuvant Anti-VEGF in Vitrectomy for Proliferative Diabetic Retinopathy: Current Evidence, Timing Considerations, and Clinical Implications.

Current ophthalmology reports·2026

Same journal

Anesthesia Strategies for Pediatric Ophthalmic Patients: Systematic Review of Recent Advances and Updates.

Current ophthalmology reports·2025

Same journal

3D Bioprinting of Cellular Therapeutic Systems in Ophthalmology: from Bioengineered Tissue to Personalized Drug Delivery.

Current ophthalmology reports·2025

Same journal

Systemic Carbonic Anhydrase Inhibitors in Common Ophthalmic Diseases: A Scoping Review from A Clinical Standpoint.

Current ophthalmology reports·2025

Same journal

Subepithelial Lesions of the Ocular Surface: A Review.

Current ophthalmology reports·2025

Same journal

Emerging Techniques in the Treatment of Conjunctival Melanoma.

Current ophthalmology reports·2025

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 2, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Molecular Biomarkers for Glaucoma.

Gala Beykin¹, Jeffrey L Goldberg¹

¹Byers Eye Institute at Stanford University, 2452 Watson Ct, Palo Alto, CA 94303.

Current Ophthalmology Reports

|November 2, 2020

Summary

This summary is machine-generated.

Researchers are exploring molecular biomarkers for glaucoma diagnosis and treatment. While advances show promise in understanding disease pathways, further research is needed for clinical application in precision medicine.

Keywords:

Glaucoma biomarkers optic nerve degeneration

More Related Videos

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Related Experiment Videos

Last Updated: Dec 2, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Area of Science:

Ophthalmology
Neuroscience
Biochemistry

Background:

Glaucoma is a leading cause of irreversible blindness.
Understanding the molecular pathogenesis of glaucomatous neurodegeneration is crucial.

Purpose of the Study:

To summarize current research on molecular biomarkers for glaucoma.
To explore their potential in diagnosis, prognosis, and treatment response.

Main Methods:

Review of current scientific literature on glaucoma molecular biomarkers.
Analysis of protein biomarkers identified in various ocular fluids and serum.

Main Results:

Significant progress in understanding glaucomatous neurodegeneration pathways.
Identification of protein biomarkers linked to inflammation and neurodegeneration in glaucoma patients.
Biomarkers found in tear film, aqueous humor, vitreous humor, and serum.

Conclusions:

Current and emerging molecular biomarkers show potential for clinical use in glaucoma.
Further studies are required to fully elucidate the molecular network.
These biomarkers may facilitate precision medicine and precision health in glaucoma management.