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A Murine Tail Lymphedema Model
Published on: February 10, 2021
Lymphovenous Anastomosis for Treating Lymphedema in IgG4-Related Disease
Ying-Sheng Lin1, Feng-Jung Yang2
1Division of Plastic and Reconstructive Surgery, National Taiwan University Hospital Yunlin Branch, Taiwan.
Abstract:
Immunoglobin G4-related disease (IgG4RD) is a multi-organ immune-mediated condition, and lymphoplasmacytic infiltration is one of the main pathologic features.1,2 Lower extremity lymphedema is likely to occur if the infiltration involves multiple inguinal lymph nodes and thus disrupting lymphatic transport. Lymphovenous anastomosis (LVA) is a surgical procedure used to treat obstructive lymphedema in extremities3,4 or in the head and neck area.5 It basically reroutes the obstructed lymph flow into patent venous system by making microsurgical anastomosis between lymphatic duct and vein over the swollen area. Herein, we reported a patient with recalcitrant lower extremity lymphedema caused by IgG4RD, whose lymphedema subsided after being treated with LVA.
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