Related Experiment Video
Updated: Dec 2, 2025

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
Published on: June 4, 2012
Purulent pericarditis in a patient with community-acquired methicillin-resistant Staphylococcus aureus: a case report
Durga Shankar Meena1, Deepak Kumar2, Maya Gopalakrishnan1
1MD, Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, 342005, Rajasthan, India.
Introduction:
The etiopathogenesis of purulent pericarditis has changed significantly in modern antibiotic era with the emergence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in the last few decades. Pericarditis due to MRSA is rarely reported in the literature without risk factors like immunosuppression, thoracic surgery, chest trauma or pre-existing pericardial diseases.
Case Report:
We describe an 18-year-old male who presented with 5 days history of fever, chest pain and shortness of breath. Echocardiogram and thorax CT showed significant pericardial effusion. The patient underwent pericardiocentesis, MRSA was isolated from blood and pericardial fluid. The patient improved with intravenous antibiotics (linezolid). Follow-up echocardiography at 3 months was unremarkable, without any residual fluid or features of constrictive pericarditis.
Discussion:
In the absence of known risk factors, MRSA is an extremely rare cause of pericarditis in modern antibiotics era. The possibility of MRSA pericarditis should be sought in every case of pericarditis to achieve prompt diagnosis and treatment.
Conclusions:
Our case highlights the role of aggressive pericardiocentesis and appropriate antibiotic therapy in purulent pericarditis.
Insights
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a rare cause of purulent pericarditis, even without risk factors. Prompt diagnosis and treatment, including pericardiocentesis and antibiotics, are crucial for recovery.
Area of Science:
- Infectious Diseases
- Cardiology
- Internal Medicine
Background:
- The landscape of purulent pericarditis has shifted due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).
- MRSA-induced pericarditis is uncommon, particularly in individuals without typical risk factors such as immunosuppression or prior thoracic procedures.
Observation:
- An 18-year-old male presented with fever, chest pain, and dyspnea.
- Imaging revealed significant pericardial effusion; MRSA was identified in blood and pericardial fluid post-pericardiocentesis.
Findings:
- The patient demonstrated clinical improvement with intravenous linezolid therapy.
- Follow-up echocardiography at three months showed complete resolution of pericardial effusion and no signs of constrictive pericarditis.
Implications:
- This case underscores that MRSA can cause pericarditis even in the absence of traditional risk factors.
- Aggressive management, including pericardiocentesis and targeted antibiotic therapy, is vital for successful outcomes in MRSA pericarditis.
Related Concept Videos
Endocarditis I: Introduction
Pericarditis I: Introduction
Pericarditis II: Clinical Features and Diagnostic Tests
Pericarditis III: Medical Management
Endocarditis III: Medical Management
Pericarditis IV: Nursing Management

