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Related Experiment Videos

Simple and compact cannula system for mice.

L Kokkinidis, L Raffler, H Anisman

    Pharmacology, Biochemistry, and Behavior
    |May 1, 1977
    PubMed
    Summary
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    Researchers developed a simple device for brain substance application in mice. Intraventricular d-amphetamine injections showed a dose-dependent increase in animal activity.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Accurate substance delivery to the brain is crucial for studying neurological processes.
    • Existing methods may limit the study of freely moving subjects.

    Purpose of the Study:

    • To present a novel, simple device for targeted substance application to the brain.
    • To validate the device's efficacy using intraventricular injections in mice.

    Main Methods:

    • Development of a small, user-friendly device for brain substance administration.
    • Intraventricular injections of d-amphetamine sulfate in freely moving mice.
    • Behavioral assessment of motor activity post-injection.

    Main Results:

    • The device enabled effective substance delivery to the brain.

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  • Intraventricular d-amphetamine sulfate (50-200 microgram) induced a dose-dependent increase in mouse activity.
  • The technique proved reliable for pharmacological studies.

    • Conclusions:

    • The described device offers a practical solution for brain substance application in research.
    • This method facilitates the study of drug effects on behavior in mobile animal models.
    • The findings support the use of this device for future neuropharmacological investigations.