Integrating Machine Learning with Human Knowledge
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Updated: Dec 2, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Changyu Deng1, Xunbi Ji1, Colton Rainey1
1Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
Machine learning has been heavily researched and widely used in many disciplines. However, achieving high accuracy requires a large amount of data that is sometimes difficult, expensive, or impractical to obtain. Integrating human knowledge into machine learning can significantly reduce data requirement, increase reliability and robustness of machine learning, and build explainable machine learning systems. This allows leveraging the vast amount of human knowledge and capability of machine learning to achieve functions and performance not available before and will facilitate the interaction between human beings and machine learning systems, making machine learning decisions understandable to humans. This paper gives an overview of the knowledge and its representations that can be integrated into machine learning and the methodology. We cover the fundamentals, current status, and recent progress of the methods, with a focus on popular and new topics. The perspectives on future directions are also discussed.
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