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Updated: Dec 2, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Modulating microenvironments for treating glioblastoma.

LaDeidra Monet Roberts1, Jennifer Munson1

  • 1Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.

Current Tissue Microenvironment Reports
|November 2, 2020
PubMed
Summary
This summary is machine-generated.

The brain tumor microenvironment significantly influences glioblastoma progression and treatment response. Understanding these interactions offers new therapeutic strategies targeting the tumor microenvironment for brain cancers.

Keywords:
Glioblastomabrain microenvironmentcancer hallmarkstumor microenvironment

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Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Glioblastoma (GBM) is the most aggressive primary brain tumor.
  • The tumor microenvironment (TME) plays a critical role in cancer development and progression.
  • Key elements of the TME, including cellular, biochemical, and biophysical cues, impact GBM behavior.

Purpose of the Study:

  • To review the development and progression of glioblastoma within the brain and its microenvironment.
  • To highlight the TME's contribution to the hallmarks of cancer.
  • To identify novel therapeutic targets within the brain TME for glioblastoma treatment.

Main Methods:

  • Literature review focusing on glioblastoma and its microenvironment.
  • Analysis of TME components and their influence on cancer hallmarks.
  • Examination of therapeutic strategies targeting the TME.

Main Results:

  • The TME contains various cellular and non-cellular components that affect glioblastoma.
  • These TME elements contribute to the established hallmarks of cancer, influencing malignancy.
  • Specific TME factors present potential targets for therapeutic intervention.

Conclusions:

  • The brain TME significantly impacts glioblastoma progression and response to therapy.
  • Applying the Hallmarks of Cancer framework reveals novel TME targets.
  • Targeting the TME offers promising avenues for treating glioblastoma and other brain cancers.