Organoid based personalized medicine: from bench to bedside

Area of Science:

• Biotechnology
• Stem Cell Research
• Organoid Technology

Background:

• Three-dimensional organoids mimic in vivo organ structure and function.
• Organoids can be derived from pluripotent or adult stem cells.
• They preserve genetic, phenotypic, and behavioral traits of original organs.

Purpose of the Study:

• To review the diverse applications of organoids in basic and translational research.
• To highlight the utility of organoids in disease modeling and drug development.
• To discuss the potential of organoids in regenerative medicine.

Main Methods:

• Organoids established from pluripotent stem cells and adult stem cells.
• Direct derivation from diseased and normal tissues.
• Genetic manipulation using CRISPR-Cas9 technology.

Main Results:

• Organoids serve as powerful in vitro models for human development and diseases (genetic, infectious, malignant).
• Patient-derived organoids show significant value in cancer and cystic fibrosis research for drug development and personalized medicine.
• Organoids demonstrate promise for applications in regenerative medicine.

Conclusions:

• Organoid technology is a versatile tool for advancing biological understanding and clinical applications.
• Organoids facilitate disease modeling, drug screening, and personalized treatment strategies.
• The review underscores the expanding role of organoids in both fundamental science and clinical translation.