Current perspective and scope of fetal therapy: part 2
Deepak Sharma1, Valentina I Tsibizova2
1Department of Neonatology, National Institute of Medical Science, Jaipur, India.
Summary
Medical fetal therapy offers a noninvasive alternative to invasive procedures for treating fetal conditions. This approach uses maternal medication transfer to safely manage conditions like neural tube defects and alloimmune thrombocytopenia.
Area of Science:
- Perinatology
- Maternal-Fetal Medicine
- Pharmacology
Background:
- Fetal therapy aims to correct fetal malformations or conditions.
- Invasive fetal therapy presents significant maternal and fetal risks.
- Noninvasive methods are crucial for conditions unsuitable for invasive treatment.
Purpose of the Study:
- To review the medical or noninvasive aspect of fetal therapy.
- To highlight advancements in managing specific fetal conditions noninvasively.
Main Methods:
- Review of medical literature on noninvasive fetal therapy.
- Analysis of conditions managed through maternal medication transfer.
Main Results:
- Medical fetal therapy avoids complications associated with invasive procedures.
- Successful noninvasive management is demonstrated for conditions including fetal and neonatal alloimmune thrombocytopenia, neural tube defect, congenital adrenal hyperplasia, perinatal infections, respiratory distress syndrome, inborn errors of metabolism, and congenital cystic adenomatoid malformation.
Conclusions:
- Medical fetal therapy is a viable and safer alternative for numerous fetal conditions.
- Progress in noninvasive fetal management offers improved outcomes and reduced risks.
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