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Related Experiment Videos

Oncogenes and surgical pathology.

S A Bartow1

  • 1Department of Pathology, University of New Mexico, School of Medicine, Albuquerque 87131.

Seminars in Diagnostic Pathology
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

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Oncogenes, viral genetic material causing cancer, are key to neoplastic transformation. Understanding their function aids in diagnosing and prognosing human neoplasia.

Area of Science:

  • Molecular Biology
  • Oncology
  • Virology

Background:

  • Oncogenes originate from viral genetic material that induces neoplasia in animals.
  • Retroviruses can alter host cellular genomes via transduction or insertional mutagenesis, creating oncogenes.
  • Approximately 20 oncogenes have been identified, implicated in neoplastic transformation.

Purpose of the Study:

  • To review functional classes of oncogenes.
  • To highlight genomic alterations associated with human neoplasia.
  • To prepare surgical pathologists for molecular diagnostic techniques.

Main Methods:

  • Review of scientific literature on oncogene discovery and function.
  • Analysis of genomic amplification, mRNA, and protein expression alterations.

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  • Examination of mutational deletions in human neoplasia.

    • Main Results:

    • Oncogene functions relate to normal cell regulatory and cycle activities.
    • Evidence mounts for oncogenes' role in neoplastic transformation.
    • Specific examples of oncogene-associated alterations in human neoplasia are reviewed.

    Conclusions:

    • Study of oncogenes elucidates the fundamental nature of neoplasia.
    • Molecular techniques for detecting oncogene alterations are becoming standard diagnostic tools.
    • Surgical pathologists must prepare for the integration of oncogene information into neoplasia diagnosis and prognosis.