Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteosarcoma chemotherapy effect: a prognostic factor.

A K Raymond1, S P Chawla, C H Carrasco

  • 1Division of Anatomic Pathology, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77030.

Seminars in Diagnostic Pathology
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors revealed: keratinocyte carcinoma following transplant.

The British journal of dermatology·2017
Same author

Of mice and men: divergent risks of teriparatide-induced osteosarcoma.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2009
Same author

Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases.

Histopathology·2005
Same author

Osteosarcoma of bone in apatient with primary hyperparathyroidism: a case report.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2003
Same author

Ciliated epithelia in the urethra: case report and literature review.

Pathology international·2002
Same author

A comparison of published head and neck stage groupings in carcinomas of the tonsillar region.

Cancer·2001

Preoperative chemotherapy significantly impacts osteosarcoma treatment outcomes. High tumor necrosis after chemotherapy strongly predicts better survival, making it a crucial prognostic factor.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Chemotherapy Research

Background:

  • Osteosarcoma treatment commonly includes chemotherapy.
  • The specific value of preoperative chemotherapy in osteosarcoma treatment is not fully established.
  • Multimodality therapy is a standard approach for osteosarcoma.

Purpose of the Study:

  • To evaluate the effectiveness of preoperative chemotherapy in osteosarcoma treatment.
  • To identify key prognostic factors influencing survival and disease-free survival.
  • To assess the role of preoperative chemotherapy in enabling limb-salvage surgery.

Main Methods:

  • A cohort of 40 osteosarcoma patients received multimodality therapy including preoperative chemotherapy (cis-platinum, adriamycin), surgery, and postoperative chemotherapy.

Related Experiment Videos

  • Histologic evaluation of tumor necrosis was used to assess response to preoperative chemotherapy.
  • Preoperative arteriograms were utilized to monitor chemotherapy response and identify residual viable tumor.

    • Main Results:

    • Overall survival was 64% and continuous disease-free survival was 58%.
    • Histologic tumor necrosis was the most significant prognostic factor: >=90% necrosis correlated with 91% disease-free survival, versus 14% with <90% necrosis.
    • Preoperative chemotherapy facilitated limb-salvage surgery in 60% of patients, up from 7% initially considered candidates.

    Conclusions:

    • Preoperative chemotherapy is a vital component of osteosarcoma treatment, significantly improving outcomes.
    • Histologic tumor necrosis is a powerful predictor of long-term disease-free survival in osteosarcoma patients.
    • Preoperative chemotherapy enhances the feasibility of limb-salvage surgery and arteriograms are effective for monitoring treatment response.