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'Sugarcoating' 2-deoxyglucose: mechanisms that suppress its toxic effects

Martin C Schmidt1, Allyson F O'Donnell2

  • 1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. mcs2@pitt.edu.

Current Genetics
|November 2, 2020
PubMed
Summary

Yeast and cancer cells share metabolic vulnerabilities. Understanding 2-deoxyglucose (2-DG) resistance pathways in yeast offers insights for developing novel cancer therapies.

Keywords:
AMP-activated protein kinaseHexose transporterPP1 phosphataseSNF1α-Arrestin

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