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High-Frequency rTMS Improves Cognitive Function by Regulating Synaptic Plasticity in Cerebral Ischemic Rats
Jiena Hong1, Jiemei Chen1, Chao Li1
1Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Neurochemical Research
|November 2, 2020
Summary
High-frequency repetitive transcranial magnetic stimulation (rTMS) effectively improves neurological and cognitive function after stroke. This treatment may work by regulating synaptic plasticity and key genes in the hippocampus.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Poststroke cognitive impairment (PSCI) is a severe consequence of stroke with limited therapeutic options.
- Repetitive transcranial magnetic stimulation (rTMS) shows potential for treating PSCI, but its mechanisms require elucidation.
Purpose of the Study:
- To investigate the therapeutic effects of high-frequency rTMS on PSCI.
- To explore the underlying molecular mechanisms of rTMS in a rat model of stroke.
Main Methods:
- A transient middle cerebral artery occlusion (tMCAO) model was used in rats.
- Neurological and cognitive functions were assessed using mNSS and MWM tests.
- RNA sequencing and bioinformatics analyses (GO, KEGG, PPI) identified differentially expressed genes (DEGs) in the hippocampus.
Main Results:
- High-frequency rTMS significantly improved neurological and cognitive functions in the tMCAO model.
- 85 DEGs were identified, with 71 upregulated and 14 downregulated in the rTMS group compared to the tMCAO group.
- DEGs were primarily involved in chemical synaptic transmission and synaptic plasticity, with notable genes including Calb2, Zic1, Kcnk9, and Grin3a.
Conclusions:
- High-frequency rTMS is a promising therapeutic strategy for PSCI.
- The mechanism of rTMS action likely involves the modulation of hippocampal synaptic plasticity and specific functional genes.
