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Published on: May 11, 2018
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Sex differences in continuous-flow ventricular assist device therapy for advanced heart failure
Yorihiko Matsumoto1, Satsuki Fukushima1, Yusuke Shimahara1
1Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.
General Thoracic and Cardiovascular Surgery
|November 2, 2020
Summary
Continuous-flow ventricular assist device (c-VAD) therapy outcomes show no sex differences in mortality or infection. However, female patients experience more non-surgical bleeding, requiring sex-specific care.
Area of Science:
- Cardiology
- Medical Devices
- Clinical Outcomes
Background:
- Sex-specific differences in continuous-flow ventricular assist device (c-VAD) therapy are not well-documented.
- Understanding these differences is crucial for optimizing patient care.
Purpose of the Study:
- To investigate sex-specific differences in clinical outcomes among Japanese patients undergoing c-VAD therapy.
- To identify potential risks and inform tailored management strategies.
Main Methods:
- Retrospective analysis of 153 patients (41 female) who received c-VAD implantation over 13 years.
- Comparison of clinical outcomes, including mortality, bleeding events, and infections, between male and female patients.
- Mean follow-up duration of 766 days.
Main Results:
- No significant sex-based differences were observed in mortality, cerebral vascular accidents, heart failure severity, or driveline infections.
- Male patients had a trend towards more surgical bleeding.
- Female patients exhibited significantly higher rates of non-surgical bleeding, primarily of gynecological origin.
Conclusions:
- Female patients on c-VAD therapy face a higher risk of non-surgical bleeding events.
- Gynecological complications and sex-specific care considerations are essential for managing female c-VAD patients.
- Further research into sex-specific management strategies for c-VAD therapy is warranted.
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