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Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats
Yeon Ju An1, Jeong Yoon Lee1, Yulha Kim1
1Department of Food Science and Nutrition, The University of Suwon, Hwasung, Korea.
Journal of Medicinal Food
|November 2, 2020
Summary
Cranberry powder (CR) effectively reduced prostate weight and key biomarkers associated with benign prostatic hyperplasia (BPH) in a rat model. These findings suggest CR as a potential functional food for managing BPH symptoms.
Area of Science:
- Urology
- Pharmacology
- Nutraceuticals
Background:
- Cranberry powder (CR) is recognized for its efficacy in managing lower urinary tract symptoms (LUTS) and recurrent urinary tract infections.
- Benign prostatic hyperplasia (BPH), prevalent in men over 50, is a significant contributor to LUTS.
Purpose of the Study:
- To investigate the potential of cranberry powder (CR) in treating benign prostatic hyperplasia (BPH).
- To evaluate CR's effects on BPH-induced changes in a rat model.
Main Methods:
- A BPH-induced rat model was established and orally administered CR.
- Rats were divided into six groups: control, castration, BPH, BPH + CR (8 weeks), BPH + CR (4 weeks), and BPH + saw palmetto.
- Prostate weight, serum and prostate dihydrotestosterone (DHT) levels, and 5-alpha reductase activity were measured.
Main Results:
- The CR8W group exhibited a significant reduction in prostate weight (33%) compared to the BPH group.
- CR administration led to decreased DHT levels (serum 18%, prostate 28%) and 5-alpha reductase activity (Type 1: 18%, Type 2: 35%).
- Histological changes indicative of BPH attenuation were observed in the CR8W group.
Conclusions:
- Cranberry powder (CR) demonstrates potential in attenuating BPH by inhibiting 5-alpha reductase and reducing prostate weight and DHT levels.
- CR may serve as a promising candidate for developing functional foods aimed at BPH treatment.
