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Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types

Mark Chandy1, June-Wha Rhee1,2, Mehmet O Ozen3

  • 1Stanford Cardiovascular Institute (M.C., J-W.R., D.R.W., L.P., C.L., H.Z., J.M., E.L., J.C.W.), Stanford University School of Medicine, CA.

Circulation
|November 2, 2020
PubMed
Abstract

No abstract available in PubMed .

Keywords:
cardiomyocytesendothelial cellsexosomesfibroblastsinduced pluripotent stem cellsmicroRNAsecretome

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...