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Updated: Dec 2, 2025
Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Neurosarcoidosis and Ocular Inflammation: A Case Series and Literature Review
Aishwary Desai1, Benjamin Chaon, Meghan Berkenstock
1Drexel University College of Medicine (AD), Philadelphia, Pennsylvania; and Ocular Immunology Division (BCC, MKB), Wilmer Eye Institute, Baltimore, Maryland.
Objective:
To describe the ocular findings of neurosarcoidosis (NS) through a case series and review the current literature on the ocular complications of NS.
Methods:
Case series of 4 patients with a literature review.
Results:
Ophthalmic involvement in NS includes scleritis, cranial nerve palsies, uveitis, optic nerve granulomas, and occlusive retinal vasculitis.
Conclusion:
NS is an uncommon, but potentially life-threatening, manifestation of sarcoidosis with ocular involvement up to 25% of patients. Patients presenting with neuro-ophthalmic manifestations of sarcoidosis are more likely to have other sites of involvement requiring ophthalmologists to maintain a high index of suspicion for systemic disease.
