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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
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Multimodal Imaging in Acute Macular Neuroretinopathy
Benjamin W Botsford1, Priyanka Kukkar, Gabrielle Bonhomme
1Department of Ophthalmology, Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Summary
A novel case of acute macular neuroretinopathy presented with visual disturbances. Optical coherence tomography and angiography revealed characteristic macular lesions and choroidal ischemia.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neuro-ophthalmology
Background:
- Acute macular neuroretinopathy is a rare condition affecting the macula.
- It is characterized by sudden onset visual disturbances.
Observation:
- A 44-year-old woman presented with bilateral irregular scotomata and photopsias.
- Ophthalmoscopy revealed bilateral, pericentral, hypopigmented, petaloid macular lesions.
- Amsler grid showed paracentral visual field defects.
Findings:
- Optical coherence tomography (OCT) demonstrated paracentral hyperreflective lesions in the outer plexiform and nuclear layers.
- Indocyanine green angiography (ICGA) indicated patches of choroidal ischemia.
Implications:
- These findings are consistent with acute macular neuroretinopathy.
- Early diagnosis and understanding of choroidal ischemia are crucial for management.
- Further research into the pathophysiology of this condition is warranted.

