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Usefulness of Tranexamic Acid Administration During Sagittal Split Ramus Osteotomy
Mitsuhiro Yoshida1, Shigehiro Ono2, Yoshitaka Shimizu3
1Section of Dental Anesthesiology, Department of Oral and Maxillofacial Surgery and Oral Medicine, Hiroshima University Hospital.
The Journal of Craniofacial Surgery
|November 2, 2020
Summary
Administering tranexamic acid before orthognathic surgery significantly reduces intraoperative bleeding and operation time. This timing also helps suppress postoperative inflammation, offering improved patient outcomes.
Area of Science:
- Oral and Maxillofacial Surgery
- Anesthesiology
- Pharmacology
Background:
- Tranexamic acid is utilized to mitigate intraoperative bleeding.
- Its impact on anti-inflammation and drainage following orthognathic surgery requires further investigation.
Purpose of the Study:
- To evaluate the efficacy of tranexamic acid in reducing intraoperative bleeding and operation time.
- To assess its effects on postoperative drainage volume and inflammatory markers after orthognathic surgery.
Main Methods:
- A comparative study involving 40 women undergoing bilateral sagittal split ramus osteotomy.
- Patients received tranexamic acid either preoperatively or postoperatively.
- Intraoperative bleeding, operation duration, drainage amount, and C-reactive protein levels were measured and compared.
Main Results:
- Preoperative administration of tranexamic acid led to significantly less intraoperative bleeding (161.7 mL vs. 270.2 mL).
- Operation time was notably shorter in the preoperative group (141.3 min vs. 166.8 min).
- Postoperative C-reactive protein levels were significantly lower, indicating reduced inflammation, in the preoperative group (3.77 mg/dL vs. 5.02 mg/dL).
- No significant difference in drainage amount was observed between the groups.
Conclusions:
- Preoperative administration of tranexamic acid is more effective in reducing intraoperative bleeding during orthognathic surgery.
- This approach also leads to shorter operation times and decreased postoperative inflammation.
- Tranexamic acid timing is crucial for optimizing outcomes in orthognathic procedures.
