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The progression rate of aortic stenosis: key to tailoring the management and potential target for treatment

Elvin Tafciu1, Giulia E Mandoli2, Ciro Santoro3

  • 1Department of Cardiology, University of Verona, Verona.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|November 2, 2020
PubMed

Insights

Aortic stenosis, a common heart valve disease, progresses variably. Understanding its determinants is crucial for tailored management and developing therapies to slow progression.

Area of Science:

  • Cardiology
  • Valvular Heart Disease
  • Echocardiography

Background:

  • Aortic stenosis is the most common valvular heart disease requiring intervention in Western countries.
  • It is characterized by progressive disease with variable rates of progression impacting prognosis.
  • Determinants of disease progression are insufficiently studied, especially in outpatient settings.

Purpose of the Study:

  • To review current knowledge on the progression rate of aortic valve stenosis.
  • To identify gaps in understanding the determinants of disease progression.
  • To explore historical and molecular aspects of aortic valve stenosis progression.

Main Methods:

  • Literature review encompassing historical, clinical, and molecular perspectives.
  • Analysis of Doppler echocardiography for assessing stenosis progression.
  • Discussion of factors influencing disease progression.

Main Results:

  • Progression rate of aortic stenosis varies significantly among individuals.
  • Doppler echocardiography is a key tool for assessing progression.
  • No proven therapies currently exist to slow the stenotic process.

Conclusions:

  • Heart valve clinics are vital for individualizing follow-up and management of aortic stenosis.
  • Further research is needed to elucidate disease progression determinants.
  • Understanding progression is key to developing future therapeutic strategies.

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