Pullulan in biomedical research and development - A review.
Ram Sarup Singh1, Navpreet Kaur1, Muhammad Hassan2
1Carbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala 147 002, Punjab, India.
International Journal of Biological Macromolecules
|November 2, 2020
Summary
Pullulan, a microbial exopolymer from Aureobasidium pullulans, offers unique biocompatible properties. Its distinct chemical structure makes it ideal for diverse biomedical applications, including drug and gene delivery.
Area of Science:
- Biochemistry
- Polymer Science
- Biotechnology
Background:
- Pullulan is a microbial exopolymer produced by Aureobasidium pullulans.
- It features repeating maltosyl units with α-(1→4) and α-(1→6) glycosidic linkages.
- These linkages confer unique physicochemical properties.
Purpose of the Study:
- To review the potential of pullulan in biomedical research and development.
- To highlight pullulan's unique properties and applications.
Main Methods:
- Literature review of pullulan's properties and applications.
- Analysis of pullulan's chemical structure and biocompatibility.
Main Results:
- Pullulan exhibits high biocompatibility, non-toxicity, and non-carcinogenicity.
- It is resistant to mutagenicity and immunogenicity.
- Its properties make it suitable for drug delivery, gene delivery, tissue engineering, and more.
Conclusions:
- Pullulan is a promising biomaterial for various biomedical applications.
- Its unique structure and safety profile support its use in advanced therapies.
- Further research can unlock its full potential in regenerative medicine and drug delivery systems.
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