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Pullulan in biomedical research and development - A review.

Ram Sarup Singh1, Navpreet Kaur1, Muhammad Hassan2

  • 1Carbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala 147 002, Punjab, India.

International Journal of Biological Macromolecules
|November 2, 2020
PubMed
Summary
This summary is machine-generated.

Pullulan, a microbial exopolymer from Aureobasidium pullulans, offers unique biocompatible properties. Its distinct chemical structure makes it ideal for diverse biomedical applications, including drug and gene delivery.

Keywords:
Biomedical industryPharmaceutical industryPullulan

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Area of Science:

  • Biochemistry
  • Polymer Science
  • Biotechnology

Background:

  • Pullulan is a microbial exopolymer produced by Aureobasidium pullulans.
  • It features repeating maltosyl units with α-(1→4) and α-(1→6) glycosidic linkages.
  • These linkages confer unique physicochemical properties.

Purpose of the Study:

  • To review the potential of pullulan in biomedical research and development.
  • To highlight pullulan's unique properties and applications.

Main Methods:

  • Literature review of pullulan's properties and applications.
  • Analysis of pullulan's chemical structure and biocompatibility.

Main Results:

  • Pullulan exhibits high biocompatibility, non-toxicity, and non-carcinogenicity.
  • It is resistant to mutagenicity and immunogenicity.
  • Its properties make it suitable for drug delivery, gene delivery, tissue engineering, and more.

Conclusions:

  • Pullulan is a promising biomaterial for various biomedical applications.
  • Its unique structure and safety profile support its use in advanced therapies.
  • Further research can unlock its full potential in regenerative medicine and drug delivery systems.