Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Highly selective vagotomy and serum gastrin levels.

D C Busman1, P J Brombacher, J D Munting

  • 1Department of Surgery, De Wever-Ziekenhuis, Heerlen, The Netherlands.

Surgery, Gynecology & Obstetrics
|November 1, 1987
PubMed
Summary

Postoperative serum gastrin levels increase after highly selective vagotomy for duodenal ulcers due to G-cell disinhibition. This rise, particularly a later secondary increase, occurs in all patients, regardless of other factors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug-induced long-QT syndrome: a case report.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2015
Same author

Theodor Billroth 1829 - 1894.

Acta chirurgica Belgica·2007
Same author

[Cannabinoid hyperemesis with the unusual symptom of compulsive bathing].

Nederlands tijdschrift voor geneeskunde·2005
Same author

[Neuroleptic malignant syndrome in users of risperidone].

Nederlands tijdschrift voor geneeskunde·2005
Same author

[Sudden death following a single oral administration of haloperidol].

Nederlands tijdschrift voor geneeskunde·2002
Same author

[Psychiatric illness does not protect against a somatic disease].

Nederlands tijdschrift voor geneeskunde·2001

Area of Science:

  • Gastroenterology
  • Surgical Research
  • Endocrinology

Background:

  • Duodenal ulcers are a common gastrointestinal condition.
  • Highly selective vagotomy is a surgical approach to reduce acid secretion.
  • Understanding postoperative hormonal changes is crucial for patient outcomes.

Purpose of the Study:

  • To investigate changes in serum gastrin levels after highly selective vagotomy.
  • To identify factors influencing postoperative gastrin levels.
  • To correlate gastrin levels with acid secretion and ulcer recurrence.

Main Methods:

  • Prospective study of 262 patients undergoing highly selective vagotomy.
  • Measurement of serum gastrin levels preoperatively and at multiple postoperative intervals.
  • Analysis of gastrin levels in relation to patient demographics, acid secretion, and recurrence.

Main Results:

  • All patients showed increased serum gastrin postoperatively.
  • A significant secondary rise in gastrin levels was observed years after surgery.
  • Preoperative cimetidine use was associated with higher gastrin values and earlier secondary increases.
  • No correlation was found between serum gastrin levels and acid secretion or recurrence.

Conclusions:

  • Proximal gastric vagotomy leads to G-cell disinhibition, causing elevated serum gastrin.
  • The secondary rise in gastrin may reflect long-term physiological adaptations.
  • Serum gastrin levels do not predict acid secretion or ulcer recurrence after this procedure.

Related Experiment Videos