A new flavanone derivative from the rhizomes of Boesenbergia pandurata

From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2-5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC₅₀ value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC₅₀, 0.83 µM).