Related Experiment Video
Updated: Dec 2, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives
Deepa Parwani1, Sushanta Bhattacharya1, Akash Rathore1
1Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar (MP), India.
Abstract:
Tuberculosis is a disease caused by Mycobacterium tuberculosis (Mtb), affecting millions of people worldwide. The emergence of drug resistance is a major problem in the successful treatment of tuberculosis. Due to the commencement of MDR-TB (multi-drug resistance) and XDR-TB (extensively drug resistance), there is a crucial need for the development of novel anti-tubercular agents with improved characteristics such as low toxicity, enhanced inhibitory activity and short duration of treatment. In this direction, various heterocyclic compounds have been synthesized and screened against Mycobacterium tuberculosis. Among them, benzimidazole and imidazole containing derivatives have been found to have potential anti-tubercular activity. The present review focuses on various imidazole and benzimidazole derivatives (from 2015-2019) with their structure-activity relationships in the treatment of tuberculosis.
Related Concept Videos
Basicity of Heterocyclic Aromatic Amines
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Antihypertensive Drugs: Thiazide-Class Diuretics
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Directing and Steric Effects in Disubstituted Benzene Derivatives
NMR Spectroscopy of Benzene Derivatives

