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Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an Orexin Receptor-Modulated Manner
Theresa E Bjorness1,2, Robert W Greene2,3,4
1Research Service, VA North Texas Health Care System, Dallas, TX 75126-7167 theresa.bjorness@va.gov.
Eneuro
|November 3, 2020
Summary
Sleep deprivation before cocaine exposure amplifies drug-seeking behavior in mice. Blocking orexin receptors reduces this effect, suggesting a therapeutic target for addiction.
Area of Science:
- Neuroscience
- Pharmacology
- Addiction Research
Background:
- Sleep disruption is common in drug addiction and withdrawal.
- The impact of sleep disruption on drug-related behaviors is not fully understood.
Purpose of the Study:
- To investigate the effects of sleep deprivation on cocaine-induced conditioned place preference (CPP) in mice.
- To explore the role of the orexin system in modulating sleep deprivation-enhanced cocaine CPP.
Main Methods:
- Mice underwent sleep deprivation (SD) before cocaine conditioning or testing.
- Cocaine conditioned place preference (CPP) was assessed.
- Orexin-1 receptor antagonism (SB 334867) was administered before conditioning or testing.
Main Results:
- SD before conditioning trials dose-dependently enhanced cocaine CPP (3 and 8 mg/kg).
- SD before postconditioning testing also enhanced cocaine CPP (8 mg/kg).
- Orexin-1 receptor antagonism attenuated SD-enhanced cocaine CPP.
Conclusions:
- Sleep deprivation exacerbates cocaine-seeking behavior.
- The orexin system plays a role in mediating the effects of sleep deprivation on drug-related behaviors.
- Orexin receptor antagonism may be a therapeutic strategy for addiction, particularly when associated with sleep disturbances.
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