Related Experiment Video

Updated: Dec 2, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
05:45

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

13.9K

Outcomes at five to eight years of age for children with Hirschsprung's disease

Benjamin Saul Raywood Allin1, Charles Opondo2, Timothy John Bradnock3

  • 1National Perinatal Epidemiology Unit, University of Oxford, Oxford, Oxfordshire, UK benjaminallin@doctors.org.uk.

Archives of Disease in Childhood
|November 3, 2020
PubMed

Insights

This study reveals that many children with Hirschsprung disease (HD) face long-term issues like incontinence and low quality of life. Addressing these core outcomes is crucial for improving patient care.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Clinical Outcomes Research

Background:

  • Hirschsprung disease (HD) is a congenital condition affecting the large intestine.
  • Long-term outcomes in children with HD require comprehensive evaluation.

Purpose of the Study:

  • To describe the core outcomes of Hirschsprung disease (HD) in UK and Irish primary school-aged children.
  • To assess functional outcomes, reoperation rates, and quality of life in a UK-wide cohort.

Main Methods:

  • Prospective cohort study (2010-2012) involving 28 UK/Irish pediatric surgical centers.
  • Data collected from birth up to 5-8 years of age, including clinical outcomes and parent/clinician reports.
  • Utilized the NETS 1HD core outcomes framework.

Main Results:

  • Of 239 children, 13% had a stoma and 9% were incontinent of urine at 5-8 years.
  • 79% maintained bowel movements without intervention, but 63% experienced fecal incontinence.
  • 44% required unplanned reoperations, and many reported lower quality of life and psychological well-being scores.

Conclusions:

  • This study provides a realistic overview of population-level outcomes for HD in school-aged children.
  • High rates of incontinence, reoperations, and reduced quality of life highlight significant challenges.
  • Prioritizing management of bladder, bowel, and psychological issues is essential for affected children.
Abstract

Keywords:
epidemiologygastroenterology

More Related Videos

Vessel-sparing Excision and Primary Anastomosis08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.8K
Immunostaining to Visualize Murine Enteric Nervous System Development07:54

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

11.8K

Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
784
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
323
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.0K
Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
578
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
283
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
653