A biodegradable microneedle sheet for intracorporeal topical hemostasis

Area of Science:

• Biomaterials Science
• Surgical Innovation
• Medical Device Development

Background:

• Effective bleeding management is crucial for patient outcomes in surgery and trauma.
• Current hemostatic products require technical advancements for enhanced efficacy and safety.
• Minimally invasive techniques and advanced materials are sought for better surgical hemostasis.

Purpose of the Study:

• To develop and evaluate a novel microneedle hemostatic sheet for improved bleeding control.
• To assess the unique features of the microneedle hemostatic sheet, including its hemostatic efficacy, safety, and mechanical properties.
• To explore potential applications of this innovative hemostatic device in clinical settings.

Main Methods:

• Development of a biodegradable microneedle hemostatic sheet utilizing microneedle technology.
• Inclusion of a mesh structure for flexibility and rigidity, and microneedles for wound fixation.
• Evaluation of hemostatic time, biodegradability, infectious risk, and mechanical properties (penetration of aorta and ventricular wall).

Main Results:

• The microneedle hemostatic sheet significantly reduced hemostatic time.
• The sheet is composed of biodegradable polymers, minimizing infectious risk for intracorporeal use.
• Microneedles effectively secured the sheet to beating swine left ventricular walls.
• The mesh structure provided both flexibility and sufficient rigidity for tissue penetration.

Conclusions:

• The developed microneedle hemostatic sheet presents a promising advancement in bleeding management.
• Its unique features offer enhanced hemostasis, secure fixation, and safety for internal use.
• Potential applications include topical hemostasis for parenchymatous organs, vessels, and heart walls during surgery or trauma.