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Related Concept Videos

Potentiometry: Membrane Electrodes01:15

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Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
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Voltammetry is an electroanalytical technique in which the current flowing through an electrochemical cell is measured as a function of applied potential, typically under conditions of concentration polarization. The technique provides valuable information about redox-active species, and the current response is plotted as a voltammogram.
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Differential-pulse voltammetry (DPV) is a type of voltammetry that involves applying a series of voltage pulses to an electrochemical cell while measuring the resulting current. In DPV, the differential pulse or small potential pulses are superimposed on a linear potential sweep. The magnitude of these pulses is typically small, often in the millivolt range. Each voltage pulse lasts a short duration, usually in the order of a few milliseconds, and is applied at regular intervals along the...
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Related Experiment Video

Updated: Dec 2, 2025

Author Spotlight: Detection of Mitophagy in Caenorhabditis elegans and Mammalian Cells Using Organelle-Specific Dyes
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A DNA-based voltmeter for organelles.

Anand Saminathan1,2, John Devany3, Aneesh Tazhe Veetil1,2

  • 1Department of Chemistry, The University of Chicago, Chicago, IL, USA.

Nature Nanotechnology
|November 3, 2020
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Summary
This summary is machine-generated.

Researchers developed Voltair, a novel fluorescent DNA nanodevice, to measure organelle membrane potential in live cells. This tool enhances understanding of organelle biology and aids in designing biocompatible electronics.

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Area of Science:

  • Cell Biology
  • Biophysics
  • Nanotechnology

Background:

  • The function of intracellular organelle membrane potential is largely unknown due to a lack of appropriate measurement tools.
  • Understanding organelle membrane potential is crucial for elucidating cellular processes.

Purpose of the Study:

  • To introduce Voltair, a novel fluorescent DNA nanodevice for measuring absolute organelle membrane potential in live cells.
  • To demonstrate Voltair's capability for organelle targeting and in situ measurements.

Main Methods:

  • Development of Voltair, a DNA nanodevice incorporating voltage-sensitive and reference fluorophores for ratiometry.
  • Utilizing Voltair as an endocytic tracer for organelle targeting.
  • Measuring membrane potential of various organelles within live cells using Voltair.

Main Results:

  • Voltair successfully measured the absolute membrane potential of different organelles in situ in live cells.
  • Voltair demonstrated effective organelle targeting and served as an endocytic tracer.

Conclusions:

  • Voltair is a valuable tool for exploring the role of organelle membrane potential in cellular functions.
  • This technology can inform the design of biocompatible electronics and advance the study of organelle biology.