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Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Towards a foundational representation of potential drug-drug interaction knowledge
Mathias Brochhausen1, Jodi Schneider2, Daniel Malone3
1Division of Biomedical Informatics, University of Arkansas for Medical Sciences, 4301 W. Markham St., #782, Little Rock, AR, 72205-7199.
Abstract:
Inadequate representation of evidence and knowledge about potential drug-drug interactions is a major factor underlying disagreements among sources of drug information that are used by clinicians. In this paper we describe the initial steps toward developing a foundational domain representation that allows tracing the evidence underlying potential drug-drug interaction knowledge. The new representation includes biological and biomedical entities represented in existing ontologies and terminologies to foster integration of data from relevant fields such as physiology, anatomy, and laboratory sciences.
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