Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.5K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.5K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

17.9K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural, histochemical, and immunocytochemical changes induced by the presence of an inquiline in a multitrophic gall context.

Plant biology (Stuttgart, Germany)·2025
Same author

Occurrence and diversity of arbuscular mycorrhizal fungi in yerba mate (Ilex paraguariensis - Aquifoliaceae) cultivation environments.

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Use of non-clinical smile images for human identification: a systematic review.

The Journal of forensic odonto-stomatology·2022
Same author

Towards a classification strategy for complex nanostructures.

Nanoscale horizons·2020
Same author

Radiography registration for mosaic tomography.

Journal of synchrotron radiation·2017
Same author

Family Members, Transplantation Candidates, and Patients Who Underwent Liver Transplantation Had Insufficient Information About the Procedure.

Transplantation proceedings·2016

Related Experiment Video

Updated: Dec 2, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.4K

Nano-targeting lessons from the SARS-CoV-2.

I R S Ribeiro1,2, R F da Silva1, C P Silveira1

  • 1Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970, Campinas, Brazil.

Nano Today
|November 3, 2020
PubMed
Summary
This summary is machine-generated.

Synthetic nanoparticles often lack targeting efficacy, causing toxicity. Viruses like SARS-CoV-2, however, offer highly ordered nanoscale scaffolds that can inspire improved synthetic nanoparticle design for better targeting and reduced side effects.

Keywords:
COVID-19Nanoparticle functionalizationResponsive targetingSARS-CoV-2Surface organizationTarget nanomedicineTargeting

More Related Videos

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
09:26

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

895
High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells
06:39

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells

Published on: April 21, 2022

3.4K

Related Experiment Videos

Last Updated: Dec 2, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.4K
Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
09:26

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

895
High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells
06:39

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells

Published on: April 21, 2022

3.4K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Virology

Background:

  • Functionalized nanoparticles often exhibit poor targeting, leading to accumulation in non-target tissues and increased toxicity.
  • Viruses, as natural nanoparticles, demonstrate precise and responsive interactions with biological systems.
  • The surface protein arrangement of viruses, such as SARS-CoV-2, is highly ordered, resembling quasi-crystalline structures.

Purpose of the Study:

  • To propose the SARS-CoV-2 virus as a model for designing targeted synthetic nanoparticles.
  • To leverage the ordered architecture of viral scaffolds for improved nanoparticle delivery systems.

Main Methods:

  • Analysis of the nanoscale architecture of SARS-CoV-2.
  • Comparative study of viral interaction mechanisms versus synthetic nanoparticle behavior.
  • Conceptual design principles for synthetic nanoparticles inspired by viral structures.

Main Results:

  • Identification of the quasi-crystalline protein distribution on the SARS-CoV-2 surface as a key feature for precise interaction.
  • Demonstration of how viral structural order can inform synthetic nanoparticle design.
  • Highlighting the potential for enhanced targeting efficacy and reduced toxicity in synthetic nanoparticles.

Conclusions:

  • The highly ordered nanoscale scaffold of SARS-CoV-2 provides a valuable blueprint for developing next-generation targeted synthetic nanoparticles.
  • Adopting viral architectural principles can overcome limitations of current nanoparticle-based therapies.
  • Future research should focus on translating viral structural insights into practical synthetic nanoparticle production.