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Updated: Dec 2, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Tobacco use disorder and the lungs
Hayden McRobbie1,2, Benjamin Kwan3,4
1National Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.
Quitting smoking significantly benefits respiratory health, reducing risks of lung cancer and COPD. Smoking cessation is a crucial, cost-effective intervention for preventing and managing lung diseases.
Area of Science:
- Pulmonology
- Public Health
- Preventive Medicine
Background:
- Tobacco smoking is a leading preventable cause of death globally.
- Smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease (COPD), and respiratory infections.
- Second-hand smoke exposure also leads to adverse respiratory effects, and smoking is linked to poorer COVID-19 outcomes.
Purpose of the Study:
- To review the impact of tobacco smoking on the respiratory system.
- To summarize the benefits of smoking cessation for respiratory health.
- To highlight the importance of smoking cessation interventions.
Main Methods:
- This is a narrative review.
- The review synthesizes existing literature on smoking's respiratory effects and cessation benefits.
Main Results:
- Smoking is a primary cause of lung cancer and COPD.
- Smoking cessation offers substantial health benefits at any age, even with existing conditions.
- Cessation support is a highly cost-effective public health intervention.
Conclusions:
- Smoking cessation is paramount for preventing and managing respiratory diseases.
- Despite available interventions, clinician offers and patient uptake of smoking cessation support are limited.
- As treatments for chronic respiratory diseases improve, smoking cessation will become increasingly vital.
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