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Related Experiment Videos

[Focal contacts and the cytoskeleton].

I S Tint, A A Neĭfakh, A D Bershadskiĭ

    Tsitologiia
    |July 1, 1987
    PubMed
    Summary

    This review details focal contacts, crucial for cell adhesion, and their associated cytoskeletal structures. It also covers how cancer affects these cell-matrix adhesion sites.

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    Role of the microtubular system in morphological organization of normal and oncogene-transfected epithelial cells.

    Proceedings of the National Academy of Sciences of the United States of America·1994

    Area of Science:

    • Cell Biology
    • Biochemistry
    • Microscopy

    Context:

    • Focal contacts are specialized cell surface domains mediating cell adhesion to the extracellular matrix.
    • These structures link the cytoskeleton to the extracellular matrix, playing a vital role in cell structure and function.

    Purpose:

    • To review light and electron microscopic methods for studying focal contacts and adhesion plaques.
    • To characterize the proteins within adhesion plaques and focal contact membranes.
    • To describe the formation and cytoskeletal associations of focal contacts in fibroblasts.

    Summary:

    • The review details the structure and function of focal contacts, including their association with actin microfilaments, microtubules, and intermediate filaments.
    • It examines the proteins involved in adhesion plaques and focal contact membranes.
    • Changes in focal contact systems and associated cytoskeletal structures during neoplastic transformation are discussed.

    Impact:

    • Provides a comprehensive overview of focal contact research, aiding cell biology and cancer research.
    • Highlights the importance of understanding cell-matrix adhesion in both normal and diseased states.
    • Offers insights into the structural basis of cell adhesion and its alterations in cancer.

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