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Twelve-Week Internet-Based Individualized Exercise Program in Adults With Systemic Lupus Erythematosus: Protocol for
Simone Cosima Boedecker1, Keito Finn Akanby Philippi2, Elmo Neuberger2
1Department of Rheumatology and Nephrology, University Medical Center Mainz, Mainz, Germany.
JMIR Research Protocols
|November 3, 2020
Summary
This study suggests internet-based exercise programs are feasible for systemic lupus erythematosus patients. Both aerobic and anaerobic training show promise for improving fitness and quality of life.
Area of Science:
- Rheumatology and Immunology
- Exercise Physiology
- Digital Health
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease linked to significant comorbidities like cardiovascular issues, metabolic disorders, muscle wasting, and fatigue.
- Exercise therapy is increasingly recognized as crucial for managing SLE comorbidities, offering benefits such as improved aerobic capacity, exercise tolerance, quality of life, and reduced depression and fatigue.
- Current evidence-based guidelines for exercise in SLE are lacking, and the effectiveness of various training modalities requires further investigation.
Purpose of the Study:
- To evaluate the feasibility, efficacy, and safety of an internet-based exercise program for patients with systemic lupus erythematosus (SLE).
- To compare the feasibility and efficiency of anaerobic training versus aerobic training in SLE patients.
Main Methods:
- A randomized controlled trial involving 30 clinically stable SLE patients assigned to aerobic exercise, anaerobic exercise, or usual care groups.
- Participants completed a 12-week supervised online exercise program with individualized weekly training plans.
- Primary outcome: change in physical fitness (VO2 peak); Secondary outcomes: disease activity markers, muscle mass, functional tests, and cell-free DNA/extracellular vesicles.
Main Results:
- The study enrolled 30 SLE patients, with 25 completing the program; no serious adverse events were reported.
- Data analysis is ongoing; preliminary findings suggest the online intervention is well-tolerated.
- Enrollment and program completion rates indicate feasibility, with detailed results pending.
Conclusions:
- Internet-based exercise interventions are anticipated to be a feasible and effective method for delivering personalized exercise to SLE patients.
- This approach holds potential for improving health outcomes and managing comorbidities in individuals with systemic lupus erythematosus.
