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Related Concept Videos

Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

1.7K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Related Experiment Video

Updated: Dec 2, 2025

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
05:36

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision

Published on: May 2, 2025

474

Determining the Indeterminate Biliary Stricture: Cholangioscopy and Beyond.

Nichol S Martinez1, Arvind J Trindade1, Divyesh V Sejpal2

  • 1Northwell Health, Zucker School of Medicine at Hofstra/Northwell, 300 Community Drive, Manhasset, NY, 11030, USA.

Current Gastroenterology Reports
|November 3, 2020
PubMed
Summary
This summary is machine-generated.

Diagnosing indeterminate biliary strictures (IDBS) is challenging. Emerging endoscopic and molecular technologies show promise in differentiating benign from malignant strictures, improving patient outcomes.

Keywords:
CholangiocarcinomaCholangioscopyConfocal laser EndomicroscopyEndoscopic ultrasoundFluorescence in situ hybridizationOptical coherence tomography

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Related Experiment Videos

Last Updated: Dec 2, 2025

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
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Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
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Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

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Area of Science:

  • Gastroenterology
  • Oncology
  • Medical Diagnostics

Background:

  • Indeterminate biliary strictures (IDBS) present a diagnostic challenge for clinicians.
  • Conventional methods like ERCP with brush cytology/biopsy have low sensitivity for malignancy.
  • Delayed diagnosis of malignant biliary strictures can negatively impact treatment and surgical options.

Purpose of the Study:

  • To review current and emerging technologies for diagnosing indeterminate biliary strictures (IDBS).
  • To highlight advancements that may improve the differentiation between benign and malignant biliary strictures.

Main Methods:

  • Review of various diagnostic technologies for IDBS.
  • Inclusion of endoscopic techniques (peroral cholangioscopy, confocal laser endomicroscopy, EUS-FNA, IDUS, OCT) and molecular pathology (FISH, NGS, integrated molecular pathology, DNA-image cytometry).

Main Results:

  • Cholangioscopy and confocal laser endomicroscopy are established in expert centers for IDBS evaluation.
  • Multiple endoscopic and molecular modalities show potential for aiding diagnosis.
  • Further prospective studies are required to validate these technologies.

Conclusions:

  • Advanced endoscopic and molecular techniques offer improved diagnostic capabilities for IDBS.
  • Continued research, including head-to-head and cost-efficacy studies, is necessary.
  • These technologies aim to reduce diagnostic delays and improve patient management for biliary strictures.