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Identification and analysis of ongoing registered clinical intervention trials on COVID-19
Luis Armando Solano-Sandí1, Mónica Cambronero-Valverde2, Guadalupe Herrera-Watson3
1Centro Especializado de Atención de Pacientes con COVID-19, Caja Costarricense del Seguro Social, San José, Costa Rica. Email: luisarmandoss93@gmail.com. Address: CENARE, La Uruca, detrás del Hospital México, San José, Costa Rica. ORCID: 0000-0001-5212-8311.
Introduction:
The World Health Organization declared the disease caused by the novel coronavirus (SARS-CoV-2), a pandemic on March 11, 2020. Several studies have been proposed and started since then, mainly covering prevention, diagnosis, management, and treatment.
Objective:
To identify and categorize all intervention studies up to the end of May related to SARS-CoV-2 infection, according to population and geo-graphical location (emphasis in Latin America) and to verify if there is any correlation according to purpose, phase, and recruitment status.
Methods:
One thousand six hundred seventy-two trials were selected from 1705 until May 24 on the World Health Organization clinical trials platform related to COVID-19. Jupyter and Python tools were used for data processing and cleaning.
Results:
One thousand six hundred seventy-two intervention studies related to SARS-CoV-2 infection were found. China, The United States, Iran, France, and Spain are the countries participating in the largest number of studies, while only 4,1% are from Latin America (mostly Brazilian). 28 studies are focusing only on older adults, and ten studies are based exclusively on populations under 19 years of age.
Conclusion:
The worldwide interest in this new disease is reflected in the increasing number of intervention studies that are being carried out to date. How-ever, the studies analyzed do not cover the most vulnerable age groups proportionally and do not have equitable participation of all the coun-tries. In Latin America, this problem is exacerbated by the region's social, economic, and political limitations. Because it is an emerging disease, there is still not enough information to establish strong correlations between the analyzed variables, and the standardization of protocols is not yet definite because most of the studies are in progress.
Insights
Global COVID-19 research shows a surge in intervention studies, but participation is unequal. Vulnerable age groups and Latin America are underrepresented in SARS-CoV-2 clinical trials.
Area of Science:
- * Global Health
- * Infectious Diseases
- * Clinical Trials
Background:
- * The novel coronavirus (SARS-CoV-2) pandemic, declared by the World Health Organization, has spurred numerous research initiatives.
- * Studies primarily focus on prevention, diagnosis, management, and treatment of SARS-CoV-2 infection.
Purpose of the Study:
- * To identify and categorize SARS-CoV-2 intervention studies globally up to May.
- * To analyze study distribution by population, geographical location (with emphasis on Latin America), purpose, phase, and recruitment status.
Main Methods:
- * A comprehensive search of the World Health Organization clinical trials platform identified 1,672 intervention studies related to COVID-19.
- * Data processing and cleaning were performed using Jupyter and Python tools.
Main Results:
- * A total of 1,672 intervention studies for SARS-CoV-2 infection were identified.
- * Leading countries in research include China, the United States, Iran, France, and Spain.
- * Latin American participation is limited (4.1%), predominantly from Brazil; studies focusing on older adults or those under 19 are also scarce.
Conclusions:
- * While global interest in addressing SARS-CoV-2 is high, intervention studies do not proportionally represent vulnerable age groups or ensure equitable geographical participation.
- * Latin America faces exacerbated challenges due to socio-economic and political limitations.
- * Insufficient data currently prevents strong correlations between study variables, and protocol standardization is ongoing as most studies are in progress.
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