Identification and analysis of ongoing registered clinical intervention trials on COVID-19

Luis Armando Solano-Sandí1, Mónica Cambronero-Valverde2, Guadalupe Herrera-Watson3

  • 1Centro Especializado de Atención de Pacientes con COVID-19, Caja Costarricense del Seguro Social, San José, Costa Rica. Email: luisarmandoss93@gmail.com. Address: CENARE, La Uruca, detrás del Hospital México, San José, Costa Rica. ORCID: 0000-0001-5212-8311.

Medwave
|November 3, 2020
PubMed
Abstract

Insights

Global COVID-19 research shows a surge in intervention studies, but participation is unequal. Vulnerable age groups and Latin America are underrepresented in SARS-CoV-2 clinical trials.

Area of Science:

  • * Global Health
  • * Infectious Diseases
  • * Clinical Trials

Background:

  • * The novel coronavirus (SARS-CoV-2) pandemic, declared by the World Health Organization, has spurred numerous research initiatives.
  • * Studies primarily focus on prevention, diagnosis, management, and treatment of SARS-CoV-2 infection.

Purpose of the Study:

  • * To identify and categorize SARS-CoV-2 intervention studies globally up to May.
  • * To analyze study distribution by population, geographical location (with emphasis on Latin America), purpose, phase, and recruitment status.

Main Methods:

  • * A comprehensive search of the World Health Organization clinical trials platform identified 1,672 intervention studies related to COVID-19.
  • * Data processing and cleaning were performed using Jupyter and Python tools.

Main Results:

  • * A total of 1,672 intervention studies for SARS-CoV-2 infection were identified.
  • * Leading countries in research include China, the United States, Iran, France, and Spain.
  • * Latin American participation is limited (4.1%), predominantly from Brazil; studies focusing on older adults or those under 19 are also scarce.

Conclusions:

  • * While global interest in addressing SARS-CoV-2 is high, intervention studies do not proportionally represent vulnerable age groups or ensure equitable geographical participation.
  • * Latin America faces exacerbated challenges due to socio-economic and political limitations.
  • * Insufficient data currently prevents strong correlations between study variables, and protocol standardization is ongoing as most studies are in progress.

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