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[HLA typing in extrinsic allergic alveolitis]
W I Litwinow1, S Müller, A G Khomenko
1Zentrales Forschungsinstitut für Tuberkulose Moskau/UdSSR.
Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1987
Abstract:
The present conceptions about the genetic mechanisms in the predisposition to extrinsic allergic alveolitis are summarized in a review. The major complex of histocompatibility is shortly characterized and the method of HLA-typing is described. The own results of HLA-typing in poultry farm workers are compared with the data from the literature on patients with pigeon-, budgerigar-keepers-disease and farmer's lung. Persons with HLA-B8- or/and DR3-antigens seem to be predisposed to extrinsic allergic alveolitis. The importance of the investigations for the preventive medicine is stressed.