AmplifEYE assisted colonoscopy versus standard colonoscopy: A randomized controlled study

Area of Science:

• Gastroenterology
• Endoscopy
• Cancer Prevention

Background:

• Colorectal cancer screening relies on effective polyp detection during colonoscopy.
• Standard colonoscopy (SC) has limitations in detecting all precancerous lesions.
• The AmplifEYE device aims to enhance mucosal visualization during colonoscopy.

Purpose of the Study:

• To compare the adenoma detection rate (ADR) of AmplifEYE-assisted colonoscopy (AC) versus standard colonoscopy (SC).
• To evaluate the impact of AmplifEYE on polyp detection rate (PDR) and serrated polyp detection rate (SDR).

Main Methods:

• A randomized controlled trial was conducted in two centers.
• Patients aged 50-79 underwent either AC or SC performed by experienced endoscopists.
• 334 patients (170 AC, 164 SC) were included in the final analysis.

Main Results:

• AmplifEYE-assisted colonoscopy showed a numerically higher ADR (47.1% vs 40.9%, P=0.253).
• Significantly higher PDR (68.2% vs 54.3%, P=0.009) and SDR (37.6% vs 20.1%, P<0.001) were observed with AC.
• Mean cecal intubation time was shorter in AC (8.0 min vs 8.9 min, P=0.030) with no significant difference in pain scores.

Conclusions:

• AmplifEYE-assisted colonoscopy significantly enhances polyp and serrated polyp detection.
• While not statistically significant, ADR was numerically higher with the AmplifEYE device.
• The device offers benefits of reduced procedure time and comparable patient comfort.