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Updated: Dec 2, 2025

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ROS-responsive probes for low-background optical imaging: a review.

Yan Xu1, Weitao Yang1, Bingbo Zhang1

  • 1Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai 200072, People's Republic of China.

Biomedical Materials (Bristol, England)
|November 3, 2020
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Summary

This review highlights advances in reactive oxygen species (ROS)-responsive probes for low-background optical imaging. These probes improve imaging quality by reducing interference signals, offering better visualization of diseases like cancer.

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Area of Science:

  • Biomedical Optics
  • Molecular Imaging
  • Nanotechnology

Background:

  • Optical imaging quality is limited by autofluorescence and background signals.
  • Low-background techniques like chemiluminescence, afterglow, and photoacoustic imaging have been developed.
  • Stimuli-responsive probes are crucial for reducing interference in imaging.

Purpose of the Study:

  • To summarize recent advances in ROS-responsive probes for low-background optical imaging.
  • To discuss methods for enhancing probe sensitivity and tissue penetration depth.
  • To explore the reaction mechanisms between ROS-responsive probes and ROS.

Main Methods:

  • Review of recent literature on ROS-responsive probes and low-background optical imaging techniques.
  • Analysis of probe reaction mechanisms with reactive oxygen species (ROS).
  • Discussion of strategies to improve imaging sensitivity and penetration depth.

Main Results:

  • ROS-responsive probes significantly reduce background signals in optical imaging.
  • Integration of ROS-responsive agents with low-background techniques enhances imaging quality.
  • Recent advances focus on improving probe sensitivity and tissue penetration.

Conclusions:

  • ROS-responsive probes are promising for advanced low-background optical imaging.
  • Understanding probe-ROS reaction mechanisms is key to developing better imaging agents.
  • This approach holds potential for improved disease visualization and diagnosis.