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Natural History of Cirrhosis: Changing Trends in Etiology Over the Years

Ramazan Idilman1, Merve Aydogan2, Mehmet Berk Oruncu2

  • 1Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey, idilman@medicine.ankara.edu.tr.

Digestive Diseases (Basel, Switzerland)
|November 3, 2020
PubMed

Insights

Hepatitis B and C are leading causes of cirrhosis and liver cancer, but nonalcoholic fatty liver disease is an increasing concern. This study tracked cirrhosis patients to understand disease progression and causes.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Epidemiology

Background:

  • Cirrhosis is a significant health concern with evolving etiological trends.
  • Understanding the natural history of cirrhosis is crucial for patient management and public health strategies.

Purpose of the Study:

  • To investigate the natural history of cirrhosis.
  • To determine the etiological trends in cirrhosis development.
  • To analyze the incidence and risk factors for hepatocellular carcinoma (HCC) in cirrhotic patients.

Main Methods:

  • A retrospective analysis of 1,341 patients diagnosed with cirrhosis between 2001 and 2018.
  • Follow-up data for 898 patients with cirrhosis for at least 6 months.
  • Logistic regression analysis to identify factors associated with HCC development.

Main Results:

  • Chronic viral hepatitis (Hepatitis B virus [HBV] and Hepatitis C virus [HCV]) was the most frequent cause (58%).
  • Nonalcoholic fatty liver disease (NAFLD)-related cirrhosis is a growing concern, potentially increasing from 1.8% to 8.0%.
  • Hepatocellular carcinoma (HCC) developed in 80 patients during follow-up, associated with older age, male gender, viral etiology, and high AST levels.

Conclusions:

  • HBV and HCV remain primary causes of cirrhosis and HCC.
  • NAFLD-related cirrhosis represents an emerging and significant public health challenge.
  • The findings highlight the need for updated strategies to address the changing landscape of cirrhosis etiology.
Abstract

Keywords:
CirrhosisHepatitis B virusHepatitis C virusHepatocellular carcinomaNonalcoholic fatty liver diseaseNonalcoholic steatohepatitis

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