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Diarrhea in the pediatric solid organ transplantation recipient: A multidisciplinary approach to diagnosis and

Abanti Chaudhuri1, Elizabeth Anne Goddard2, Michael Green3

  • 1Department of Pediatrics, Division of Nephrology, Stanford University, Stanford, CA, USA.

Pediatric Transplantation
|November 3, 2020
PubMed

Insights

Diarrhea is common in pediatric solid organ transplant (SOT) recipients, impacting their health. A systematic approach is needed for accurate diagnosis and timely treatment of diarrhea in these immunocompromised children.

Area of Science:

  • Pediatric Gastroenterology
  • Transplant Medicine
  • Immunology

Background:

  • Diarrhea is a frequent complication in pediatric solid organ transplantation (SOT) recipients.
  • It is associated with significant morbidity and reduced quality of life.
  • Limited data exist on the epidemiology, diagnosis, and treatment of diarrhea in this population.

Purpose of the Study:

  • To review current literature on diarrhea in pediatric SOT recipients.
  • To propose a systematic, stepwise diagnostic approach for diarrhea in this high-risk group.
  • To guide timely diagnosis and management of both infectious and non-infectious causes.

Main Methods:

  • Systematic review of published data on diarrhea in pediatric SOT recipients.
  • Proposal of a structured diagnostic and management strategy.
  • Focus on identifying infectious and non-infectious etiologies.

Main Results:

  • Pediatric SOT recipients are at increased risk due to immunosuppression, exposures, and polypharmacy.
  • Standardized evaluation is crucial for accurate diagnosis and prompt treatment.
  • The proposed approach aims to facilitate focused management.

Conclusions:

  • A systematic approach is needed to evaluate and manage diarrhea in pediatric SOT recipients.
  • Further prospective studies are required to understand prevalence, risk factors, and complications.
  • Development of vaccines and antiviral therapies could improve outcomes.

Keywords:
diarrheapediatricsolid organ transplantation

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