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A facile injectable carbon dot/oxidative polysaccharide hydrogel with potent self-healing and high antibacterial
Xu Yang1, Peili Li1, Wentao Tang1
1School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Abstract:
Bacterial infection is one of the most formidable problems in wound healing, which inflicts severe pain on patients while causing wound ulceration. Here, we prepared an injectable self-healing carbon dot hydrogel with outstanding antibacterial activity only using ε-poly(L-lysine) carbon dot (PL-CD) and oxidized dextran (ODA). The particle size of PL-CD prepared by pyrolysis of poly-l-lysine was about 3 nm. Moreover, PL-CD with abundant -NH2 on its surface could not only act as nodes to connect ODA through Schiff base to construct PL-CD@ODA hydrogel network, but also offer excellent antibacterial properties. As the contacting and releasing antibacterial action of the PL-CD@ODA hydrogel, nearly 100 % of the 107 CFU/mL of S. aureus was killed after 10 min of contacting. In addition, PL-CD@ODA hydrogel showed flexible injectability and extremely strong self-healing properties after being severely damaged. When 1000 % shear stress applied to the hydrogel, complete healing could be achieved within a few seconds.
