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Published on: June 23, 2020
Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy
Min Li1, Jiao Sun2, Wenjun Zhang3
1State Key Laboratory of the Fine Chemicals, Dalian University of Technology, Dalian 116023, PR China; Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education of Life Sciences, Dalian Minzu University, Dalian 116600, PR China.
Abstract:
The polysaccharide-based biomaterials hyaluronic acid (HA) and chondroitin sulfate (CS) have aroused great interest for use in drug delivery systems for tumor therapy, as they have outstanding biocompatibility and great targeting ability for cluster determinant 44 (CD44). In addition, modified HA and CS can self-assemble into micelles or micellar nanoparticles (NPs) for targeted drug delivery. This review discusses the formation of HA- and CS-based NPs, and various types of CS-based NPs including CS-drug conjugates, CS-polymer NPs, CS-small molecule NPs, polyelectrolyte nanocomplexes (PECs), CS-metal NPs, and nanogels. We then focus on the applications of HA- and CS-based NPs in tumor chemotherapy, gene therapy, photothermal therapy (PTT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and immunotherapy. Finally, this review is expected to provide guidelines for the development of various HA- and CS-based NPs used in multiple cancer therapies.
