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Biologically active PET/polysaccharide-based nanofibers post-treated with selenium/Tragacanth Gum nanobiocomposites
Sara Jalali1, Majid Montazer2, Mahnaz Mahmoudi Rad3
1Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran.
Carbohydrate Polymers
|November 4, 2020
Summary
Tragacanth gum (TG) and PET nanofibers stabilized with selenium nanoparticles (Se NPs) demonstrated enhanced antioxidant and wound healing properties. The SeNPs/TG formulation showed significant potential for biomedical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Polysaccharide-based nanofibers offer versatile platforms for biomedical applications.
- Selenium nanoparticles (Se NPs) possess notable antioxidant and antimicrobial properties.
- Tragacanth gum (TG) is a natural polysaccharide with potential stabilizing capabilities.
Purpose of the Study:
- To synthesize and characterize selenium nanoparticles stabilized with Tragacanth gum (SeNPs/TG).
- To evaluate the antioxidant and antimicrobial activities of SeNPs/TG.
- To assess the efficacy of SeNPs/TG-treated nanofibers in wound healing applications.
Main Methods:
- Synthesis of Se NPs and SeNPs/TG.
- Characterization using Dynamic Light Scattering (DLS), Field Emission Scanning Electron Microscopy (FE-SEM), Energy-Dispersive X-ray spectroscopy (EDX), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD).
- Fourier Transform Infrared Spectroscopy (FTIR) for chemical bonding analysis.
- DPPH scavenging assay for antioxidant activity.
- Antimicrobial testing against Staphylococcus aureus and Candida albicans.
- In vitro wound healing assay using fibroblast cell migration.
Main Results:
- Successful synthesis and stabilization of Se NPs with TG, indicated by FTIR.
- TEM and DLS confirmed a narrower size distribution for SeNPs/TG compared to Se NPs.
- SeNPs/TG exhibited significantly higher antioxidant activity (DPPH scavenging).
- Remarkable inhibition of Staphylococcus aureus and Candida albicans by Se NPs and SeNPs/TG solutions.
- No significant antibacterial activity observed on the treated nanofibers themselves.
- Uniform migration of fibroblast cells on SeNPs/TG-treated nanofibers, indicating effective wound healing potential.
Conclusions:
- SeNPs/TG demonstrates superior antioxidant properties and potential for wound healing.
- The TG stabilization enhances Se NP characteristics and suitability for biomedical uses.
- These findings highlight the therapeutic value of SeNPs/TG for advanced medical applications.
