Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the veil of cell death.

Cell chemical biology·2026
Same author

High-throughput, organ-scale 3D tubule tracking using TubuleMAP.

Research square·2026
Same author

STING-STAT3-SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Soft-Templated Sol-Gel Synthesis of Mesoporous Perovskite-Type Multicomponent Metal Oxide (Bi<sub>0.2</sub>Na<sub>0.2</sub>K<sub>0.2</sub>La<sub>0.2</sub>Sr<sub>0.2</sub>)TiO<sub>3</sub> and Its Enhanced Photocatalytic Activity.

ACS omega·2026
Same author

A Multi-Class Intra-Trial Trajectory Analysis Technique to Visualize and Quantify Variability of Mental Imagery EEG Signals.

International journal of neural systems·2025
Same author

Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors.

Molecular cancer research : MCR·2025

Related Experiment Video

Updated: Dec 2, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

11.7K

Polydopamine Antioxidant Hydrogels for Wound Healing Applications.

Naphtali A O'Connor1,2, Abdulhaq Syed1, Madeline Wong1

  • 1Department of Chemistry, Lehman College of the City University of New York, Bronx, NY 10468, USA.

Gels (Basel, Switzerland)
|November 4, 2020
PubMed
Summary

Polydopamine (PDA) hydrogels show significant antioxidant activity, enhancing wound healing. Dextran hydrogels crosslinked with PDA and polyethylene imine (PEI)-PDA copolymers demonstrate improved antioxidant properties and cell migration for therapeutic applications.

Keywords:
antioxidantbiomaterialshydrogelspolydopaminewound healing

More Related Videos

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

2.8K
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

4.8K

Related Experiment Videos

Last Updated: Dec 2, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

11.7K
Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

2.8K
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

4.8K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Antioxidants accelerate wound healing, making them key therapeutic targets for chronic wounds.
  • Dopamine, a neurotransmitter, possesses inherent antioxidant properties and can be polymerized into polydopamine (PDA).

Purpose of the Study:

  • To demonstrate polydopamine (PDA) as an antioxidant biomaterial for wound healing applications.
  • To synthesize and characterize dextran-based hydrogels incorporating PDA and a polyethylene imine-polydopamine (PEI-PDA) copolymer.

Main Methods:

  • Utilized established methodology for crosslinking polysaccharides with polyamines using epichlorohydrin and NaOH.
  • Prepared dextran hydrogels crosslinked with PDA and PEI-PDA copolymer, varying dopamine feed ratios.
  • Assessed hydrogel properties including visual incorporation of PDA, morphology, strength, and antioxidant activity via a radical scavenging assay.

Main Results:

  • Hydrogel darkening indicated successful PDA incorporation, with PEI-PDA copolymers yielding sturdier, darker gels.
  • Hydrogel morphology and strength were tunable based on dopamine feed ratios.
  • PDA-containing hydrogels exhibited significant antioxidant activity, with a 0.5 dopamine to dextran ratio hydrogel scavenging 78.8% of radicals, compared to 1.4% for controls.
  • An ex vivo assay showed considerable cell migration on the PEI-PDA hydrogel.

Conclusions:

  • Polydopamine is a viable antioxidant biomaterial for hydrogel development.
  • Dextran hydrogels crosslinked with PDA and PEI-PDA copolymers show promise for enhancing wound healing due to their antioxidant capacity and ability to support cell migration.