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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
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Chronic Active Epstein-Barr Virus Infection: Is It Immunodeficiency, Malignancy, or Both?
Shigeyoshi Fujiwara1,2, Hiroyuki Nakamura2
1Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Cancers
|November 4, 2020
Summary
Chronic active Epstein-Barr virus (EBV) infection causes prolonged illness and is linked to T or NK cell proliferation. Genetic factors may predispose individuals to this rare syndrome, which has varied outcomes.
Area of Science:
- Virology
- Immunology
- Genetics
Background:
- Chronic active Epstein-Barr virus (CAEBV) infection is a rare syndrome.
- Characterized by persistent infectious mononucleosis-like symptoms and high EBV DNA levels in immunocompetent individuals.
- Primarily reported in East Asia and Latin America, suggesting genetic predisposition.
Purpose of the Study:
- To summarize recent findings on CAEBV.
- To discuss current understanding of its pathogenesis and disease concept.
- To highlight critical unsolved questions in CAEBV research.
Main Methods:
- Review of recent genetic analyses of viral and host genomes in CAEBV patients.
- Clinicopathological investigations.
- Summary of existing literature on CAEBV.
Main Results:
- EBV in CAEBV often induces proliferation of T or natural killer (NK) cells.
- CAEBV presents a heterogeneous clinical course, ranging from indolent to aggressive with fatal outcomes.
- Pathogenesis involves aspects of both neoplasm and immunodeficiency.
Conclusions:
- Recent genetic discoveries are improving the understanding of CAEBV.
- Further research is needed to clarify the pathogenesis and disease concept of CAEBV.
- Understanding genetic predispositions and viral-host interactions is crucial for CAEBV management.
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