Clinical Applications of Visual Plasmonic Colorimetric Sensing

Area of Science:

• Nanotechnology
• Biochemistry
• Analytical Chemistry

Background:

• Colorimetric analysis is crucial for plasmonic biosensor operationalization.
• Metal nanoparticles' unique properties facilitate colorimetric sensing.
• Localized surface plasmon resonance (LSPR) extinction enables clinical diagnostics and drug monitoring.

Purpose of the Study:

• Review recent advancements in biochemical monitoring using plasmonic colorimetric strategies.
• Discuss distance- or morphology/size-dependent sensing modes for biomarker detection.
• Evaluate colorimetric nanosensors for point-of-care applications with naked-eye detection.

Main Methods:

• Summarizing progress in plasmonic colorimetric strategies for biomarker detection.
• Analyzing distance- and morphology/size-dependent sensing modes.
• Reviewing applications for pharmaceuticals, proteins, carbohydrates, nucleic acids, bacteria, and viruses (e.g., SARS-CoV-2).

Main Results:

• Plasmonic colorimetric biosensors demonstrate ultrasensitive detection capabilities.
• Nanosensors are suitable for point-of-care devices with naked-eye readout.
• Effective detection across diverse analytes including infectious agents.

Conclusions:

• Plasmonic colorimetric assays are practical for rapid visual readout in biological samples.
• Nanosensors hold significant potential for clinical diagnostics and drug monitoring.
• Future perspectives include overcoming current challenges for broader adoption.