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Cardiovascular Manifestations of COVID-19
Sneha Nandy1, Siu-Hin Wan1, Jorge Brenes-Salazar1
1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, United States.
Insights
This review examines the cardiovascular effects of COVID-19, a respiratory illness caused by SARS-CoV-2. It highlights how pre-existing heart conditions impact COVID-19 outcomes and details new cardiac complications arising from the infection.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has led to a global health crisis.
- COVID-19 primarily manifests as a respiratory illness, ranging from mild symptoms to severe pneumonia and ARDS.
- Patients with cardiovascular risk factors are at increased risk and may experience worsened conditions.
Purpose of the Study:
- To review the cardiovascular manifestations of COVID-19 reported in the literature.
- To outline the impact of pre-existing cardiovascular disease on COVID-19 clinical course and outcomes.
- To detail de novo cardiac complications associated with COVID-19 infection.
Main Methods:
- Literature review of published studies on COVID-19 and cardiovascular manifestations.
- Analysis of reported cases detailing cardiac complications.
- Examination of the influence of cardiovascular risk factors on COVID-19 prognosis.
Main Results:
- COVID-19 infection can lead to de novo cardiac complications, including myocardial injury and arrhythmias.
- Pre-existing cardiovascular disease and risk factors are associated with increased susceptibility and poorer outcomes in COVID-19 patients.
- The review synthesizes current knowledge on the multifaceted cardiovascular impact of SARS-CoV-2.
Conclusions:
- COVID-19 presents significant cardiovascular challenges beyond its respiratory effects.
- Understanding these cardiovascular manifestations is crucial for managing COVID-19 patients, particularly those with underlying heart conditions.
- Further research is needed to fully elucidate the long-term cardiovascular consequences of SARS-CoV-2 infection.
Abstract:
Coronavirus disease 2019 (COVID-19) first emerged in a group of patients who presented with severe pneumonia in Wuhan, China, in December 2019. A novel virus, now called SARSCoV- 2 (Severe Acute Respiratory Syndrome Coronavirus-2), was isolated from lower respiratory tract samples. The current outbreak of infection has spread to over 100 countries and killed more than 340,000 people as of 25th May, 2020. The predominant clinical manifestation of COVID-19 is a respiratory disease- ranging from mild flu-like symptoms to fulminant pneumonia and Acute Respiratory Distress Syndrome (ARDS). Patients with pre-existing cardiovascular risk factors are considered more susceptible to the virus, and these conditions are often worsened by the infection. Furthermore, COVID-19 infection has led to de novo cardiac complications, like acute myocardial injury and arrhythmias. In this review, we have focused on the cardiovascular manifestations of COVID-19 infection that have been reported in the literature so far. We have also outlined the effect of pre-existing cardiovascular disease as well as risk factors on the clinical course and outcomes of COVID-19 infection.
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