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Diabetic Neuropathy Pain Management: A Global Challenge.

Zunaira Qureshi¹, Murtaza N Ali¹

¹Department of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, H-12, 44000, Islamabad, Pakistan.

Current Diabetes Reviews

|November 4, 2020

Summary

Painful diabetic neuropathy (PDN) affects many people with diabetes, with current treatments offering limited relief. Future treatments should target altered skin factors for better pain management.

Keywords:

PDN management Pathogenesis of painful diabetic neuropathy alterations in diabetic skin classification of painful diabetic neuropathy cutaneous alterations in PDN diabetic foot.diabetic neuropathy management localized drug delivery pDSPN

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Area of Science:

Neurology
Diabetology
Pharmacology

Background:

Painful diabetic neuropathy (PDN) is a prevalent complication of diabetes mellitus, significantly impacting patient quality of life and increasing healthcare costs.
Existing treatments for PDN are only partially effective and associated with considerable side effects, highlighting a need for improved therapeutic strategies.
The complex pathogenesis of PDN remains incompletely understood due to challenges in nerve sample acquisition and the lack of non-invasive diagnostic methods.

Purpose of the Study:

To review the current understanding of PDN pathogenesis.
To describe the clinical manifestations of PDN.
To explore available and potential treatment options for PDN.

Main Methods:

A comprehensive literature search was conducted using PubMed and Google Scholar with relevant keywords.
Data from selected studies were systematically analyzed and compiled for synthesis.

Main Results:

The review provides a simplified overview of PDN for new researchers, clarifying common misconceptions.
Changes in skin structure and function associated with diabetes, diabetic neuropathy, and PDN are discussed.
The limitations of current PDN pain relievers underscore the necessity of identifying and targeting altered microenvironmental factors for novel theranostic approaches.

Conclusions:

Future therapeutic strategies for PDN should consider alterations in skin structure, function, and microenvironment in diabetic patients.
Development of smart, targeted, and stimuli-responsive treatments is proposed to maximize pain relief.
Minimizing side effects through precisely tailored treatments is a key objective for managing PDN.