Related Experiment Video

Updated: Dec 2, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.7K

Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

Congcong Ding1, Yang Chen1, Yumeng Shi1

  • 1Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi Province, China.

Lipids in Health and Disease
|November 4, 2020
PubMed

Insights

Nontraditional lipid profiles like the LDL-C/HDL-C ratio are linked to a higher risk of peripheral artery disease (PAD) in hypertensive patients. These lipid indices can aid in cardiovascular disease risk stratification.

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Public Health

Background:

  • Limited data exist on nontraditional lipid profiles and peripheral artery disease (PAD) risk.
  • This study investigated lipid indices (TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, non-HDL-C) in relation to PAD in hypertensive individuals.

Purpose of the Study:

  • To examine the association between nontraditional lipid profiles and PAD risk.
  • To identify which lipid indices are most effective for PAD prediction in hypertensive patients.

Main Methods:

  • Cross-sectional study of 10,900 hypertensive adults.
  • PAD diagnosis based on ankle-brachial index (ABI) < 0.9.
  • Analysis using multivariate logistic regression and restricted cubic splines.

Main Results:

  • All nontraditional lipid indices showed a positive, dose-response association with PAD.
  • Increased TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C were linked to significantly higher PAD risk (37%, 14%, 40%, 24% per SD increment, respectively).
  • Highest tertiles of LDL-C/HDL-C and TC/HDL-C ratios showed the strongest association with PAD.

Conclusions:

  • Nontraditional lipid indices are positively associated with PAD in Chinese hypertensive adults.
  • LDL-C/HDL-C and TC/HDL-C ratios demonstrated superior predictive value for PAD.
  • Findings can enhance cardiovascular disease risk stratification and dyslipidemia management.
Abstract

Keywords:
Ankle-brachial indexChinese adultsCholesterolEpidemiologyHypertensionNontraditional lipid profilesPeripheral artery disease

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.3K

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
185
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
200
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
142
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
212
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
521
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
281