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Updated: Dec 2, 2025

A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants

A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants

Published on: October 10, 2022

GBAF, a small BAF sub-complex with big implications: a systematic review.

Sarah M Innis¹, Birgit Cabot²

¹Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.

Epigenetics & Chromatin

|November 4, 2020

Summary

The GBAF complex, a SWI/SNF chromatin remodeler, plays a key role in mammalian development and disease. Understanding GBAF function is vital for reproductive applications and developing new therapies.

Keywords:

Chromatin remodeling Embryonic development Epigenetic modification Gene expression Neurodevelopment Oncogene Pluripotency Tumor suppressor

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Last Updated: Dec 2, 2025

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Published on: July 11, 2013

Area of Science:

Molecular Biology
Genetics
Cell Biology

Background:

ATP-dependent chromatin remodelers, including SWI/SNF family complexes, are essential for gene transcription and chromatin organization.
Distinct SWI/SNF complexes (BAF, PBAF, GBAF, esBAF, npBAF/nBAF) have implications in development and disease.
The GBAF subcomplex is increasingly recognized for its role in mammalian development.

Purpose of the Study:

To review the roles of the SWI/SNF chromatin remodeling subcomplex GBAF and its subunits.
To highlight the involvement of GBAF in mammalian development and disease processes.

Main Methods:

Literature review of studies on GBAF complex and its subunits.
Analysis of GBAF's involvement in cellular differentiation, development, and disease.

Main Results:

GBAF complex and its components are linked to crucial events in mammalian development.
Aberrant expression of GBAF components is associated with neurodevelopmental disorders and malignancies.

Conclusions:

Knowledge of GBAF complex function is essential for advancing mammalian reproductive applications.
Understanding GBAF is crucial for developing effective therapeutic interventions and strategies for related diseases.